炎症后色素沉着:病因、发病机制与治疗Post-inflammatory hyperpigmentation:etiology,pathogenesis,and treatment
张凡;冯巾娣;
摘要(Abstract):
炎症后色素沉着是指皮肤在急性或慢性炎症过程之后出现的皮肤色素沉着,是一种非常常见的色素性皮肤病,可发生于任何年龄段,以有色人种,如亚洲人较为多见,且持续时间较久,影响患者的日常生活。目前对于该病的相关研究较少,认识有限,本文旨在阐述炎症后色素沉着的病因及发病机制,并对现存的治疗手段加以总结。
关键词(KeyWords): 炎症后色素沉着;病因;发病机制;治疗
基金项目(Foundation): 2021年度北京积水潭医院自然基金培育计划
作者(Authors): 张凡;冯巾娣;
DOI: 10.19593/j.issn.2095-0721.2023.01.010
参考文献(References):
- [1]Taylor,S.,Grimes,P.,Lim,J.,Im,S.&Lui,H.Postinflammatory hyperpigmentation.J Cutan Med Surg 13,183-191,doi:10.2310/7750.2009.08077(2009).
- [2]Halder,R.M.&Nootheti,P.K.Ethnic skin disorders overview.J Am Acad Dermatol 48,S143-148,doi:10.1067/mjd.2003.274(2003).
- [3]Leal-Silva,H.Predicting the risk of postinflammatory hyperpigmentation:The palmar creases pigmentation scale.J Cosmet Dermatol 20,1263-1270,doi:10.1111/jocd.13968(2021).
- [4]Darji,K.,Varade,R.,West,D.,Armbrecht,E.S.&Guo,M.A.Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris.J Clin Aesthet Dermatol 10,18-23(2017).
- [5]Lawrence,E.&Al Aboud,K.M.in StatPearls(StatPearls PublishingCopyright?2021,StatPearls Publishing LLC.,2021).
- [6]D avis,E.C.&Callender,V.D.Postinflammatory hyperpigmentation:a review of the epidemiology,clinical features,and treatment options in skin of color.J Clin Aesthet Dermatol 3,20-31(2010).
- [7]Pillaiyar,T.,Manickam,M.&Jung,S.H.Recent development of signaling pathways inhibitors of melanogenesis.Cell Signal 40,99-115,doi:10.1016/j.cellsig.2017.09.004(2017).
- [8]Lamel,S.A.,Rahvar,M.&Maibach,H.I.Postinflammatory hyperpigmentation secondary to external insult:an overview of the quantitative analysis of pigmentation. Cutan Ocul Toxicol 32,67-71,doi:10.3109/15569527.2012.684419(2013).
- [9]Tomita,Y.,Maeda,K.&Tagami,H.Mechanisms for hyperpigmentation in postinflammatory pigmentation,urticaria pigmentosa and sunburn.Dermatologica 179 Suppl 1,49-53,doi:10.1159/000248449(1989).
- [10]Serre,C.,Busuttil,V.&Botto,J.M.Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation.Int J Cosmet Sci 40,328-347,doi:10.1111/ics.12466(2018).
- [11]Ortonne,J.P.&Bissett,D.L.Latest insights into skin hyperpigmentation.J Investig Dermatol Symp Proc 13,10-14,doi:10.1038/jidsy mp.2008.7(2008).
- [12]Pillaiyar,T.,Namasivayam,V.,Manickam,M.&Jung,S.H.Inhibitors of Melanogenesis:An Updated Review.J Med Chem61,7395-7418,doi:10.1021/acs.jmedchem.7b00967(2018).
- [13]Medrano,E.E.et al.Chronic growth stimulation of human adult melanocytes by inflammatory mediators in vitro:implications for nevus formation and initial steps in melanocyte oncogenesis.Proc Natl Acad Sci U S A 90,1790-1794,doi:10.1073/pnas.90.5.1790(1993).
- [14]Carreira,S.et al.Mitf regulation of Dial controls melanoma proliferation and invasiveness.Genes Dev 20,3426-3439,doi:10.1101/gad.406406(2006).
- [15]Tomita,Y.,Maeda,K.&Tagami,H.Melanocyte-stimulating properties of arachidonic acid metabolites:possible role in postinflammatory pigmentation.Pigment Cell Res 5,357-361,doi:10.1111/j.1600-0749.1992.tb00562.x(1992).
- [16]Gordon,P.R.,Mansur,C.P.&Gilchrest,B.A.Regulation of human melanocyte growth,dendricity,and melanization by keratinocyte derived factors.J Invest Dermatol 92,565-572,doi:10.1111/1523-1747.ep12709595(1989).
- [17]Nordlund,J.J.The pigmentary system and inflammation.Pigment Cell Res 5,362-365,doi:10.1111/j.1600-0749.1992.tb00563.x(1992).
- [18]Sriwiriyanont,P.,Ohuchi,A.,Hachiya,A.,Visscher,M.O.&Boissy,R.E.Interaction between stem cell factor and endothelin-1:effects on melanogenesis in human skin xenografts.Lab Invest 86,1115-1125,doi:10.1038/labmyest.3700469(2006).
- [19]张凡,邱婉宁,杨一诺,冯巾娣.VISIA对湿性愈合疗法治疗面部炎症性疾病临床疗效的定量评价.中国医疗美容12,57-60,doi:10.19593/j.issn.2095-0721.2022.01.016(2022).
- [20]Techapichetvanich,T.et al.The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing:A split-face randomizedcontrolled study.J Cosmet Dermatol 17.756-761.doi:10.1111/jocd.12691(2018).
- [21]Wattanakrai,P.,Sindhusen,S.&Ploydaeng,M.Effectiveness of an epidermal growth factor-containing cream on postinflammatory hyperpigmentation after 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser treatment of acquired bilateral nevus of Ota-like macules(Hori's nevus)in Asians:A split-face,double-blinded,randomized controlled study.J Cosmet Dermatol,doi:10.1111/jocd.14765(2022).
- [22]Youn,S.W.In vivo model for postinflammatory hyperpigmentation:a step forward.Br J Dermatol 174,721-722,doi:10.1111/bjd.14333(2016).
- [23]Isedeh,P.et al.An in vivo model for po stinflammatory hyperpigmentation:an analysis of histological,spectroscopic.colorimetric and clinical traits.Br J Dermatol 174,862-868,doi:10.1111/bjd.14184(2016).
- [24]Lyons,A.B.,Kohli,I.,Lim,H.W.&Hamzavi,I.H.Insights on an in vivo model for po stinflammatory hyperpigmentation.Br J Dermatol 181,598-599,doi:10.1111/bjd.17746(2019).
- [25]Nakano,S.et al.Establishment of a mouse model for postinflammatory hyperpigmentation.Pigment Cell Melanoma Res34,101-110,doi:10.1111/pcmr.12911(2021).
- [26]Park,J.Y.et al.Two histopathological patterns of po stinflammatory hyperpigmentation:epidermal and dermal.J Cutan Pathol 44,118-124,doi:10.1111/cup.12849(2017).
- [27]Lacz,N.L.,Vafaie,J.,Kihiczak,N.I.&Schwartz,R.A.Postinflammatory hyperpigmentation:a common but troubling condition.Int J Dermatol 43,362-365,doi:10.1111/j.1365-4632.2004.02267.x(2004).
- [28]Masu,S.&Seiji.M.Pigmentary incontinence in fixed drug eruptions.Histologic and electron microscopic findings.J Am Acad Dermatol 8,525-532,doi:10.1016/s0190-9622(83)70060-5(1983).
- [29]Fatima,S.,Braunberger,T.,Mohammad,T.F.,Kohli,I.&Hamzavi,I.H.The Role of Sunscreen in Melasma and Postinflammatory Hyperpigmentation.Indian J Dermatol 6 5,5-10,doi:10.4103/ijd.IJD_295_18(2020).
- [30]Grayson,C.&Heath,C.R.Dupilumab Improves Atopic Dermatitis and Post-Inflammatory Hyperpigmentation in Patient With Skin of Color.J Drugs Dermatol 19,776-778,doi:10.36849/jdd.2020.4937(2020).
- [31]Chaowattanapanit,S.,Silpa-Archa,N.,Kohli,I.,Lim,H.W.&Hamzavi,I.Po stinflammatory hyperpigmentation:A comprehensive overview:Treatment options and prevention.J Am Acad Dermatol 77,607-621,doi:10.1016/j.jaad.2017.01.036(2017).
- [32]Tan,M.G.et al.Topical treatment for po stinflammatory hyperpigmentation:a systematic review.J Dermatolog Treat, 1-9,doi:10.1080/09546634.2021.1981814(2021).
- [33]吴亭妍et al.纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效研究.中国美容医学25,87-90,doi:10.15909/j.cnki.cn61-1347/r.001351(2016).
- [34]Kim,M.S.et al.Tranexamic Acid Diminishes Laser-Induced Melanogenesis.Ann Dermatol 27,250-256,doi:10.5021/ad.2015.27.3.250(2015).
- [35]Lindgren,A.L.,Austin,A.H.&Welsh,K.M.The Use of Tranexamic Acid to Prevent and Treat Post-Inflammatory Hyperpigmentation. J Drugs Dermatol 20,344-345,doi:10.36849/jdd.5622(2021).
- [36]Huerth,K.A.,Hassan,S.&Callender,V.D.Therapeutic Insights in Melasma and Hyperpigmentation Management.J Drugs Dermatol 18,718-729(2019).
- [37]Kaufman,B.P.,Aman,T.&Alexis,A.F.Po stinflammatory Hyperpigmentation:Epidemiology,Clinical Presentation,Pathogenesis and Treatment.Am J Clin Dermatol 19,489-503,doi:10.1007/s40257-017-0333-6(2018).